Capsaicin Powder

Product  Details

Xi'an Kintaihealth® stands as a leading producer of premium Capsaicin Powder (CAS: 404-86-4). Through cutting-edge extraction and purification techniques, we provide pharmaceutical-grade products, maintaining capsaicin in its most bioactive state. This ensures optimal absorption and effectiveness across various applications. Our strict quality control measures guarantee consistency in purity and potency, making our Capsaicin Powder a reliable choice for industries seeking high-quality natural ingredients. Whether for use in topical analgesics, dietary supplements, or pharmaceutical research, our product's superior bioavailability supports the development of top-tier formulations.

  What is Capsaicin Powder?  

Capsaicin powder is an extremely spicy vanilloid alkaloid with strong irritation. It is the spicy ingredient in chili peppers and the source of the medicinal ingredients in chili peppers. Studies have shown that capsaicin has strong analgesic, anti-inflammatory and anti-fatigue effects. It can also cause the skin blood vessels to swell slightly, improve microcirculation, and reduce the risk of heart disease and stroke.

  Kintai Capsaicin Powder Advantages  

High Potency & Clinically - Backed Efficacy

Kintai's Capsaicin Powder (CAS: 404-86-4) delivers pharmaceutical-grade quality with purity ≥98% verified by HPLC analysis. Clinically validated for its potent bioactivity, capsaicin targets vanilloid receptor TRPV1, exhibiting significant analgesic, anti-inflammatory, and thermogenic effects. Studies show it reduces neuropathic pain by desensitizing sensory neurons and accelerates muscle recovery by promoting blood circulation. The powder maintains its bioactive form through advanced extraction technologies, ensuring consistent efficacy in topical analgesics, weight management supplements, and pharmaceutical research. Each batch undergoes rigorous testing for bioactivity, guaranteeing reliable performance across applications.

Multi - Industry Application

· Pharmaceuticals & Healthcare:

· Topical creams/gels for arthritis, neuropathy, and post-surgical pain relief, leveraging its ability to block pain signal transmission.

· Oral supplements for metabolic support, as capsaicin increases energy expenditure and fat oxidation.

· Food & Beverage:

· Natural spice additive for flavor enhancement (Scoville units 可调), with antibacterial properties extending product shelf life.

· Functional ingredients in weight-loss drinks or thermogenic formulas.

· Agriculture & Pest Control:

· Bio-pesticide to repel insects (e.g., aphids, rodents) due to its pungent activity, offering an eco-friendly alternative to synthetic chemicals.

· Cosmetics & Personal Care:

· Anti-cellulite creams to stimulate microcirculation, and hair growth serums to activate hair follicle receptors.

Strict Quality Control

Manufactured in GMP-compliant facilities, Kintai’s Capsaicin Powder ensures end-to-end quality assurance:

· Purity Testing: HPLC analysis confirms ≥98% capsaicin content, with controls for heavy metals (Pb≤2ppm, As≤1ppm) and residual solvents (ethanol≤5000ppm).

· Microbial Safety: Total plate count ≤1000cfu/g, yeast/mold ≤100cfu/g, and absence of pathogens (E. coli, salmonella).

· Documentation: Each batch is accompanied by COA, MSDS, and traceability records, complying with international standards (FDA, EFSA, WHO).

· Process Validation: Extraction techniques (e.g., supercritical CO₂ fluid extraction) are validated for consistency, minimizing batch-to-batch variation.

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  Capsaicin Powder Quality Specification & Standard  

  Production Process of Capsaicin Extraction  

1. Raw Material Pretreatment

· Select mature, red-colored, spicy chili peppers free of mildew.

· Wash to remove sand, dirt, and impurities (e.g., chili stems).

· Dry to 8%-12% moisture content, avoiding high temperatures (recommended hot air ≤45℃ to preserve active ingredients).

· Break the peppers and separate seeds from peels (capsaicin mainly resides in peels).

· Grind into 40-60 mesh particles to increase solvent contact area.

2. Solvent Extraction

· Common solvents: 95% ethanol (food-grade), acetone, n-hexane, or other organic solvents.

· Extraction methods:

· Ambient temperature maceration: Mix chili powder with solvent and steep statically for 48 hours (suitable for small-scale production).

· Countercurrent extraction: Industrial-scale use of pressure-resistant extraction tanks where solvent and raw material contact reversely to enhance efficiency.

· Reflux extraction: Heat under reflux for 20-30 minutes to shorten extraction time.

3. Preliminary Concentration & Solvent Recovery

· Filter the extraction liquid to remove residues.

· Recover solvents via vacuum distillation or evaporation to obtain crude capsicum oleoresin.

4. Purification & Refinement

· De-colorization and impurity removal: Treat with alkali solution or adsorb with activated carbon to eliminate pigments and odors.

· Molecular distillation: Separate high-purity capsaicin under low-temperature and vacuum conditions to avoid thermal degradation.

· Supercritical CO₂ extraction (optional): Achieve solvent-free residue and direct high-purity product (requires high-pressure equipment).

5. Finished Product Preparation

· Standardize and blend the concentrated solution to produce liquid capsaicin extract or crystalline powder.

· Residues (chili meal) can be processed into feed or further extracted for other components.

  Capsaicin Powder Benefits  

Potent Analgesic Effects
Capsaicin is a natural pain reliever that works by desensitizing sensory neurons, making it effective for managing neuropathic pain, arthritis, and muscle soreness. Topical applications reduce pain signals by depleting substance P, a neurotransmitter responsible for transmitting pain impulses. Studies show it provides significant relief for conditions like post-herpetic neuralgia and diabetic neuropathy, often used in creams, patches, or gels for targeted relief.

Anti-Inflammatory Properties
By inhibiting pro-inflammatory cytokines and reducing oxidative stress, capsaicin helps alleviate inflammation. It targets the TRPV1 receptor, which regulates immune responses and inflammation, making it useful in supplements or topical treatments for joint inflammation, tendonitis, and post-workout recovery. Its anti-inflammatory effects also support respiratory health by reducing nasal congestion when used in nasal sprays or inhalants.

Metabolic and Weight Management Support
Capsaicin boosts metabolism by increasing thermogenesis, the process by which the body generates heat and burns calories. It can raise energy expenditure by 5–10% and enhance fat oxidation, making it a popular ingredient in weight-loss supplements. Additionally, it may suppress appetite by stimulating satiety signals, helping to reduce calorie intake when consumed in moderate doses.

Cardiovascular Health Benefits
Research suggests capsaicin may improve heart health by lowering blood pressure and cholesterol levels. It enhances blood vessel dilation, improves blood flow, and reduces platelet aggregation, thereby decreasing the risk of cardiovascular diseases. Consuming capsaicin regularly (e.g., in dietary supplements) may support overall circulatory function and heart health.

Antimicrobial and Anticancer Potential
Capsaicin exhibits antibacterial activity against pathogens like Staphylococcus aureus and E. coli, making it a natural preservative in food products. In research, it shows promise in inhibiting cancer cell growth by inducing apoptosis (programmed cell death) in tumor cells, particularly in prostate, breast, and pancreatic cancer studies. While more clinical trials are needed, these properties highlight its potential in pharmaceutical research.

Skin and Hair Health Enhancement
Topical capsaicin stimulates blood circulation in the skin, promoting collagen production and improving skin texture. It’s used in anti-aging creams to reduce wrinkles and in hair growth products to activate hair follicles, potentially preventing hair loss. When formulated in low concentrations, it can also soothe itchy skin and reduce dandruff by regulating sebum production.

Gastrointestinal Health Support
Despite its spicy reputation, capsaicin can benefit digestion by increasing saliva production and promoting stomach acid secretion, which aids nutrient absorption. It may also protect the stomach lining by reducing inflammation and inhibiting the growth of Helicobacter pylori, a bacterium linked to ulcers. However, high doses may irritate the gastrointestinal tract in sensitive individuals.

Cognitive Function and Neuroprotection
Studies suggest capsaicin may support brain health by reducing oxidative stress and inflammation in the nervous system. It has been associated with a lower risk of neurodegenerative diseases like Alzheimer’s and Parkinson’s, as well as improved memory and cognitive performance. Its ability to cross the blood-brain barrier allows it to directly influence neuronal health and function.

  Capsaicin Powder Apllications  

1. Analgesia and antipruritic effect: Capsaicin can affect the release and storage of nerves, thereby achieving the effects of analgesia and antipruritic effect. It has been widely used to treat diseases such as arthritis, muscle pain, back pain, sports sprains and post-herpetic neuralgia.

2. Promote blood circulation: It can dilate blood vessels, promote blood circulation, help improve heart function, increase cardiac output, reduce myocardial oxygen consumption, and improve myocardial ischemia.

3. Heat resistance and sterilization: Capsaicin powder can inhibit the synthesis of prostaglandins in the hypothalamic regulatory center and vascular wall, causing peripheral blood vessels to dilate and sweat to achieve the effect of antipyretic. At the same time, it can also interfere with the oxidative metabolism process in bacteria, which helps to kill bacteria.

4. Anti-inflammatory: It has the effect of reducing inflammatory reactions, such as its application in certain inflammatory diseases.

5. Assisted weight loss: It can promote metabolism, increase energy consumption, and help control weight.

6. Treatment of skin diseases: It has a certain effect on skin diseases such as psoriasis and frostbite.

7. Industrial application: Capsaicin in high-spiciness peppers is an important industrial raw material, which can be made into special products such as paints, anesthetics and even tear gas.

Interested? We’d Love to Send You a Sample!

  Capsaicin Powder Dosage Recommendation  

  Safety Profile of Kintai's Capsaicin Powder  

1. Toxicological Considerations

· Acute Toxicity:
Capsaicin (CAS: 404-86-4) is a natural alkaloid with low acute toxicity. Animal studies show oral LD₅₀ values > 2000 mg/kg in rodents, indicating minimal risk from accidental ingestion at standard doses. Kintai’s products undergo acute toxicity testing to ensure compliance with international safety standards (e.g., FDA, EFSA).

· Chronic Exposure Risks:
Prolonged exposure to high concentrations (e.g., >0.1% in topical products) may cause skin irritation or gastrointestinal discomfort (e.g., heartburn, nausea). Kintai’s quality controls limit residual solvents and impurities to mitigate long-term risks, with chronic toxicity data available upon request.

· Target Organ Effects:
Inhalation of fine powder may irritate the respiratory tract; topical application on broken skin may cause burning sensations. Clinical studies show no systemic toxicity at recommended doses.

2. Quality Control & Safety Certifications

 Purity & Purity Testing:

· Pharmaceutical-grade capsaicin powder maintains ≥98% purity via HPLC analysis, with batch-specific testing for:

· Heavy metals (Pb ≤2ppm, As ≤1ppm)

· Residual solvents (ethanol ≤5000ppm)

· Microbial safety (total plate count ≤1000cfu/g, pathogens negative)

 Manufacturing Standards:

· Produced in GMP-compliant facilities with end-to-end traceability.

· Each batch is accompanied by:

· Certificate of Analysis (COA)

· Material Safety Data Sheet (MSDS)

· Compliance with ICH guidelines for pharmaceutical ingredients

 Testing Protocols:

· Stability testing under accelerated conditions (40℃/75% RH) to ensure product shelf life (typically 24 months).

· Particle size analysis (40–60 mesh) for consistent solubility and bioavailability.

3. Safety Warnings & Limitations

 Contraindications & Restrictions:

· Pregnant/Lactating Women: Oral use not recommended due to limited safety data; topical use should be supervised by a healthcare provider.

· Children & Sensitive Populations: Avoid topical application on children under 12 years; oral supplements not suitable for individuals with gastrointestinal ulcers or IBS.

· Adverse Reactions & Overexposure:

· Topical: Skin redness, burning, or blistering at concentrations >0.1%; rinse with water and discontinue use.

· Oral: Nausea, vomiting, or abdominal cramps if exceeding 500 mg/day; seek medical attention for severe symptoms.

Handling & Storage Precautions:

· Physical Hazards: Wear gloves and a dust mask when handling powder to prevent inhalation/skin contact.

· Storage: Store in a cool (≤25℃), dry place away from light and moisture, sealed in original packaging.

· Disposal: Follow local regulations for chemical waste, especially solvent-contaminated materials.

· Use Restrictions:

· Intended for industrial, research, or pharmaceutical use only unless approved for specific consumer applications (e.g., OTC pain creams).

· Not for direct human consumption without regulatory approval (e.g., as a dietary supplement ingredient).

Key Safety Summary Table

Interested? We’d Love to Send You a Sample!

  OEM and ODM Services  

At KINTAI, we understand the significance of customization. Our Original Equipment Manufacturing( OEM) and Original Design Manufacturing( ODM) services empower you to conform it to meet your specific conditions. This inflexibility, coupled with our intertwined service results, ensures that your unique vision is brought to life seamlessly.

  KINTAI Certifications  

  Advantage Of KINTAI  

KINTAI is a professional manufacturer and supplier of capsaicin powder, We have our own research and development center, production base, and state-of-the-art equipment. With multiple patents and certifications, we guarantee the highest quality and safety of our products. We provide comprehensive OEM and ODM services, ensuring customized products and integrated solutions. With fast delivery and secure packaging, we are your trusted partner in choosing your product. For more information, please contact us at info@kintaibio.com.

  Parcel and Shipping  

1> 1KG/bag, 10KG/carton, 25kg/drum
2> By Express: Door to door; DHL/FEDEX/EMS; 3-4DAYS; Suitable for under 50kg; high cost; easy to pick up the goods
3> By Air: Airport to Airport; 4-5 days; Suitable for more than 50kg; high cost; professional broker needed
4> By Sea: Port to Port; 15-30days; Suitable for more than 500kg; Low cost; professional broker needed