Tetrahydrocurcumin Powder

Tetrahydrocurcumin(THC) is hydrogenated from curcumin isolated from the rhizome of turmeric, and is a natural cosmetic whitening raw material. Tetrahydrocurcumin has strong activity of inhibiting tyrosinase, can effectively inhibit the generation of free radicals and remove free radicals in the body, has obvious antioxidant effect, can resist skin aging, fade stains, darkness and so on.

Xi'an Healthkintai^® is a leading producer of premium Tetrahydrocurcumin Powder, delivering pharmaceutical-grade quality with purity consistently exceeding 98% through advanced extraction and purification technologies. As a key hydrogenated derivative of curcumin (CAS: 36071-41-3), Tetrahydrocurcumin exists in its core bioactive form, ensuring high bioavailability and stability for diverse applications. Our GMP-compliant production process guarantees superior stability and reliability for use in anti-aging functional foods, dietary supplements for oxidative stress relief, cosmeceuticals for skin brightening, and pharmaceutical research focused on anti-inflammatory and neuroprotective formulations.If you want to buy Tetrahydrocurcumin,you can contact us at health@kintaibio.com.

1. Safety and Toxicity Research

• General Safety Limits :No universally standardized upper limit exists for tetrahydrocurcumin intake. Clinical trials typically use doses ranging from 100–300 mg/day without significant adverse effects. Doses exceeding 500 mg/day may increase the risk of mild gastrointestinal symptoms (e.g., bloating, diarrhea).
• Toxicity Data :Animal studies (rats) indicate the acute oral LD₅₀ of tetrahydrocurcumin exceeds 2,000 mg/kg, indicating low acute toxicity. Long-term studies (up to 12 months) at doses of 200–400 mg/day report no severe systemic toxicity.
• Purity and Quality :Kintai’s Tetrahydrocurcumin is produced using advanced hydrogenation and purification technologies, achieving pharmaceutical-grade purity of ≥98% (verified by HPLC). Rigorous testing ensures minimal contaminants, including heavy metals (e.g., lead, arsenic) and residual solvents, meeting global quality standards.

2. International Compliance

• EU Regulations : Tetrahydrocurcumin is recognized as a safe ingredient for use in food supplements and nutraceuticals within the EU, provided it meets required purity and safety criteria.
• US FDA : The FDA has not established specific regulations for tetrahydrocurcumin as a dietary supplement ingredient. However, when used in pharmaceuticals or food additives, it must comply with Good Manufacturing Practice (GMP) guidelines.
• Asia : In countries such as China, Japan, and South Korea, tetrahydrocurcumin is approved for use in dietary supplements, functional foods, and cosmeceuticals, adhering to local purity and safety standards.

As a metabolite of curcumin, tetrahydrocurcumin has superior stability and bioavailability to curcumin. Studies have shown that tetrahydrocurcumin has a wide range of biological activities, including antioxidant, anti-inflammatory, and melanin inhibition, and has great potential for development in the field of whitening and freckle removal.

At a safe dose, tetrahydrocurcumin reduced the production of NO, an inflammatory indicator, in RAW264.7 cells in a concentration-dependent manner. Human efficacy trial results showed that after using 0.5% tetrahydrocurcumin whitening cream for 4 weeks, the subjects' individual angle-like ITA° values ​​and melanin index were significantly improved, indicating that tetrahydrocurcumin has obvious freckle-removing and whitening effects.

 [1] ZHAO W, YANG A, WANG J, et al. Potential application of natural bioactive compounds as skin‐whitening agents: A review[J]. Journal of Cosmetic Dermatology, 2022, 21（12）: 6669-6687.[2] JABLONSKI N G. The evolution of human skin pigmentation involved the interactions of genetic, environmental, and cultural variables[J]. Pigment Cell & Melanoma Research, 2021, 34（4）: 707-729.

1. Powerful Anti-Inflammation

Tetrahydrocurcumin precisely inhibits core inflammatory signaling pathways such as NF-κB, reducing the production of various pro-inflammatory factors such as TNF-α and IL-6. This mechanism makes it particularly valuable for managing chronic inflammatory diseases such as arthritis and enteritis. It effectively relieves inflammation-related symptoms such as joint swelling and pain, abdominal discomfort, and creates a low-inflammatory environment within the body.

2. Excellent Antioxidant

Its molecular structure endows it with powerful free radical scavenging abilities, with antioxidant activity even superior to that of standard curcumin. It directly neutralizes and reduces oxidative damage to cells, DNA, and proteins by free radicals, thereby slowing the aging process, protecting vital organs such as the cardiovascular system and liver, and preventing various chronic diseases caused by oxidative stress.

3. Neuroprotective

This is one of its most prominent advantages. Tetrahydrocurcumin Powder efficiently crosses the blood-brain barrier and directly acts on the central nervous system. It not only inhibits the accumulation of beta-amyloid plaques, thereby preventing Alzheimer's disease, but also promotes the synthesis of brain-derived neurotrophic factor (BDNF), promoting neuronal regeneration and connectivity, significantly improving memory and learning abilities, and exhibiting potential as an antidepressant and anxiolytic.

4. Protecting the Liver

Through its dual anti-inflammatory and antioxidant mechanisms, tetrahydrocurcumin effectively protects the liver. It can reduce oxidative stress and inflammation in the liver caused by toxins and drugs, inhibit hepatic stellate cell activation, and play a positive role in preventing and treating non-alcoholic fatty liver disease and slowing the progression of liver fibrosis.

5. Benefiting the Skin

Its anti-inflammatory properties help alleviate skin problems such as acne and eczema. Furthermore, by inhibiting tyrosinase activity and neutralizing UV-induced free radicals, it effectively reduces melanin production, lightens dark spots, and slows down photoaging, achieving skin whitening and anti-aging effects from within.

6. Auxiliary Cancer Prevention

Preclinical studies have shown that tetrahydrocurcumin can inhibit the growth of various cancer cells through multiple pathways, including inducing apoptosis and inhibiting proliferation and angiogenesis. While further human trials are needed to verify this, it holds considerable potential as a natural candidate for cancer prevention and adjuvant therapy.

1. Dietary Supplements and Health Foods

This is the core application industry for tetrahydrocurcumin. As a high-end ingredient, it is widely used in dietary supplements for joint health, brain power enhancement, liver protection, hangover relief, and comprehensive anti-aging. Compared to traditional curcumin products, its "high absorption and piperine-free" selling points are highly competitive in the market, satisfying consumer demand for effective and convenient health supplements and driving product upgrades in related categories.

2. Functional Foods and Beverages

Tetrahydrocurcumin is being innovatively incorporated into functional drinks, protein bars, dairy products, and healthy snacks. It imbues these common foods with specific health benefits such as "anti-inflammatory," "refreshing," "joint protection," or "intrinsic anti-aging," catering to consumers' increasing trend toward proactive health management through daily diet, enhancing product added value and market differentiation.

3. Skincare and Beauty

In the cosmetics industry, tetrahydrocurcumin has become a popular high-end active ingredient. It is primarily used in anti-allergy, soothing, whitening, and anti-aging skincare products. Its inherent anti-inflammatory properties help improve sensitive skin conditions like acne and redness. Furthermore, its potent antioxidant capacity combats photoaging and, by inhibiting melanin production, achieves a brighter, more radiant complexion, satisfying the market's demand for "endogenous skincare" ingredients.

4. Pharmaceutical and Biotechnology Industry

In the pharmaceutical field, Tetrahydrocurcumin Powder demonstrates significant application potential. It is being intensively studied as a potential candidate for the prevention of neurodegenerative diseases (such as Alzheimer's disease), as an adjunct to anti-tumor drugs, and for the treatment of metabolic syndrome. Its excellent neuroprotective activity and low toxicity hold promise for future development as a new prescription-grade drug or a specific health food for medical purposes.

1.High Potency & Clinically Proven Efficacy : Our Tetrahydrocurcumin is available in Pharmaceutical Grade (≥98% purity) and Nutraceutical Grade (≥95% purity), rigorously analyzed by HPLC to ensure outstanding antioxidant, anti - inflammatory, and photostable properties. Every batch guarantees consistent bioactivity, enabling the development of premium-grade products.

2.Multi - Industry Application :

• Nutraceuticals : Oxidative stress reducer, supports liver health, and aids in joint comfort for dietary supplements.
• Cosmetics : Enhances skin brightness, reduces melanin formation, and promotes a even complexion as a key ingredient in anti - pigmentation skincare formulations.
• Pharmaceuticals : Potential applications in research for neuroprotective, anti - arthritic, and metabolic syndrome - related therapies.

3.Strict Quality Control : Manufactured in a GMP - compliant facility, our Tetrahydrocurcumin Powder offers complete traceability, accompanied by detailed COA, MSDS, and comprehensive testing for heavy metals, residual solvents, and microbial contaminants.

Q1:What is the role of Tetrahydrocurcumin in disease prevention and treatment?

 A1:It regulates NF-κB, reduces inflammation, promotes cancer cell apoptosis, inhibits tumor angiogenesis, and enhances antioxidants, aiding in treating inflammation-related cancers.

Q2:What is more powerful than curcumin?

A2:Tetrahydrocurcumin has been reported to have health promoting benefits. It has been shown to have greater anti-inflammatory potency than curcumin.