Aconite Root Aconitum Kusnezoffii Extract

Healthkintai^® is a professional manufacturer and supplier of plant extracts, committed to providing pharmaceutical companies with high-standard, safe, and reliable botanical active ingredient raw materials. Our Aconite Root extract (Aconite kusnezoffii Reichb.) is derived from the dried root tubers of the Ranunculaceae plant. Using modern, standardized extraction processes, we precisely control the content of toxic components such as diester alkaloids, ensuring product consistency and safety from the source while preserving its traditional medicinal value.

We further utilize proprietary technology to isolate and purify the primary analgesic active ingredient, lappaconitine hydrobromide, from the Aconite extract. Ultimately, this extract is converted into a chemical active pharmaceutical ingredient (API) with a well-defined structure, stable physicochemical properties, and a purity of 96%. We have a large-scale production facility and ensure comprehensive quality control and stable supply from the plant source to the final API. We fully support your company's research and application in the development of new non-addictive analgesics and dosage form improvements, jointly providing the market with superior modern pharmaceutical solutions. If you require high-quality lappaconitine hydrobromide, please contact us at health@kintaibio.com.

1. Toxicity Symptoms and Historical Warnings
Highly Toxic Properties: The toxins contained in Aconitum napellus are extremely toxic, earning it the historical title of "King of Poisons."
Symptoms of Poisoning: After ingestion or contact, symptoms develop rapidly and include:
Early symptoms: Numbness around the mouth, vomiting, and paresthesias (tingling or a crawling sensation).
Late symptoms: These symptoms can rapidly worsen into fatal cardiac arrhythmias and severe hypotension.
Detectability: Modern forensic techniques (such as liquid chromatography-mass spectrometry) can accurately detect aconitine postmortem, providing unequivocal evidence.
2. Strict Warnings and Professional Use
Only Legal Use: Our raw materials are licensed only to qualified, professional pharmaceutical companies for the legal extraction of lappaconitine hydrobromide.
Strict Prohibitions: Personal self-medication, folk remedies, or any other illegal use is strictly prohibited. Any misuse or abuse will result in extremely serious consequences.

Aconitum plants are mostly used as medicine using their tubers or roots, which are highly effective in relieving pain. Aconitum Kusnezoffii Extract is a highly toxic and pyrogenic herb and should not be used raw. it must be processed before clinical use. Lactapoxetine is widely used to treat mild to moderate pain, and is particularly effective in acute and chronic pain, neuropathic pain, and cancer pain. Its analgesic effect is long-lasting, non-addictive, and does not cause cumulative toxicity.

Aconitum-derived Chinese herbal medicines and their preparations hold great promise for clinical application and future development. The alkaloids and many derivatives found in Aconitum-derived Chinese herbal medicines are highly effective in relieving pain, making them potent potential analgesics. However, in actual use, toxicity must be carefully considered to ensure safe use.

(Reference:Study on the analgesic effect of Aconitum and its preparations,Research progress on the chemical components and analgesic activities of diterpenoid alkaloids from Aconitum plants in recent years) 

1. Powerful Analgesic Effect
The core benefit of Aconite Root extract is analgesia. It is a non-addictive analgesic with a strong and long-lasting analgesic effect. Its mechanism of action is primarily through blocking sodium ion channels, inhibiting nerve signal transmission, thereby exerting analgesic effects at both the central and peripheral levels. It is suitable for moderate to severe pain, such as cancer pain, postoperative pain, and traumatic pain, with significant efficacy, and is unlikely to develop tolerance or dependence with long-term use.

2. Anti-inflammatory and Detumescent Effects
This drug exhibits both anti-inflammatory properties, effectively inhibiting the release and exudation of inflammatory mediators, and reducing local tissue redness, swelling, heat, and pain. Therefore, when used to treat inflammatory pain conditions such as arthritis, sprains, and rheumatoid arthritis, it not only relieves pain but also helps control the development of inflammation at the root cause, promoting the reduction of swelling, achieving a comprehensive treatment of both the symptoms and the root cause.

3. Antipyretic and Antipyretic Effects
lappaconitine hydrobromide has a strong antipyretic effect on fever symptoms caused by pathogen infection or other causes. It acts on the hypothalamic thermoregulatory center, increasing the activity of the heat dissipation process and restoring its normal regulatory function, thereby reducing elevated body temperature to normal levels. This effect makes it valuable for alleviating fever symptoms associated with colds, flu, and other illnesses.

4. Local Anesthetic and Sedative Effects
Like other aconite alkaloids, lappaconitine hydrobromide exhibits a local anesthetic effect, reversibly blocking the generation and transmission of sensory nerve impulses. Furthermore, it has a mild sedative effect, helping to alleviate tension, anxiety, and restlessness caused by severe pain, creating a more conducive state for rest and recovery.

1. Injection: For strong intervention in acute and severe cases
This is the most critical dosage form of Aconite Root extract in emergency clinical care. It is typically a purified, strictly quality-controlled, single-ingredient injection (such as aconitine hydrochloride injection). Its primary efficacy is to restore yang and rescue the adverse condition. It is used to treat yang-deficient syndromes caused by heart failure, shock, and other conditions, characterized by profuse sweating, cold extremities, and a weak pulse. This dosage form is rapid and potent, rapidly strengthening the heart and raising blood pressure. However, it also carries the highest risk and is therefore reserved for use by experienced physicians in hospitals.

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2. Oral tablets: For long-term treatment of chronic, intractable arthritis
This is typically a compound tablet or capsule formulated after standardized processing (such as processed Chuanwu and processed Fupian) and combined with other traditional Chinese medicines. Its primary efficacy is to warm the meridians, dispel cold, relieve numbness, and alleviate pain. It is commonly used to treat chronic diseases characterized by wind-cold-dampness arthritis, such as rheumatoid arthritis and osteoarthritis, relieving symptoms such as cold joint pain and difficulty flexing and extending. Oral tablets must be used strictly according to a physician's instructions, ensuring individualized dosage and close monitoring for potential toxic and side effects.

3. Topical Patches: A Relatively Safe Option for Local Analgesia
Aconitum Kusnezoffii Extract is combined with other blood-activating and analgesic herbs to form a gel patch or poultice, which is applied directly to the painful joint or area. Through transdermal absorption, it exerts local anesthetic and anti-inflammatory analgesic effects, and is used to relieve pain caused by frozen shoulder, knee osteoarthritis, and traumatic injuries. Compared to oral formulations, topical patches have lower systemic absorption and are safer. However, caution is advised against using them on broken skin and long-term, large-area applications.

• Superior Quality: Kintai's lappaconitine hydrobromide uses high-quality Aconitum napellus raw materials from authentic production areas and utilizes modern extraction and purification processes. Our product consistently achieves purity exceeding 96%, with key impurity levels far below international pharmacopoeia standards. This ensures the safety and efficacy consistency of the final drug from the source, providing you with a stable and reliable raw material guarantee.
• International Certifications: Our production system has achieved multiple international certifications, including GMP, ISO, HACCP, and HALAL. This demonstrates that the entire process, from raw materials to finished product, complies with the most stringent pharmaceutical manufacturing practices in mainstream global markets, ensuring your formulation products enter the international market smoothly and gain widespread trust.
• Flexible Customization: We deeply understand the differentiated needs of innovative drugs. Kintai offers professional customization services, allowing us to flexibly adjust key parameters such as crystal form, particle size, and bulk density to meet your specific formulation development goals (such as different dosage forms, strengths, or release characteristics), making us a trusted, long-term partner.