Betulin Powder

Betulin Powder is a triterpenoid compound extracted from birch bark, which has mild anti-cancer, bactericidal, antiviral, anti-ultraviolet, anti-inflammatory, rapid wound healing, anti-allergy, anti-aging and other effects, and can also improve the luster of damaged hair and promote hair growth. It is widely used in food, medicine, daily chemical industry and other fields, and is a very valuable natural substance. It can be obtained from rich plant resources.

Xi'an Healthkintai^® is a leading manufacturer of betulin, providing high-quality, high-standard betulin. Betulin exhibits significant anti-inflammatory, antioxidant, and antiviral properties, effectively inhibiting cancer cell proliferation and inducing apoptosis, making it a key component of anti-cancer drug development. Furthermore, this ingredient is used in skincare products for soothing, barrier repair, and anti-aging. If you would like to purchase premium betulin, please contact us directly!

Kintai Betulin Powder Advantages

• Guaranteed High Efficacy: Our carefully selected, high-purity betulin raw material boasts activity far exceeding market standards and authoritatively validated superior bioavailability, ensuring significant and stable core benefits such as anti-inflammatory, antioxidant, and repair.
• High-Standard Quality Control: We strictly adhere to international Good Manufacturing Practices for Pharmaceuticals, implementing comprehensive quality control from raw material traceability to finished product delivery. We rigorously test purity, activity, and safety indicators for consistent, reliable quality.
• Customized Services: We offer customized products with varying purity, dosage forms, and dissolution options based on specific application scenarios and formulation requirements. We also provide professional technical support to help you create differentiated end products.

Extract Source

Kintai's high-quality betulin is meticulously sourced from the very beginning. We select high-quality birch trees from the high-altitude regions of Northeast China, ensuring high standards and quality for our raw materials. Through specialized extraction processes, we ensure high-purity betulin.

KINTAI Betulin Powder Production process

• Raw Material Pretreatment and Extraction：Birch bark is dried and pulverized. Betulin is dissolved and separated from the raw material using an organic solvent via reflux or Soxhlet extraction to obtain a crude extract.
• Concentration and Preliminary Purification：The crude extract is recovered by vacuum distillation and the solvent is concentrated to obtain a dark paste extract. Preliminary purification is then performed by precipitation to remove impurities.
• Deep Purification and Refining：Column chromatography is used for key separation, utilizing differences in solvent polarity to selectively elute and collect fractions rich in betulin. Finally, recrystallization is performed to obtain a highly pure white crystalline product.

Betulin, a natural compound extracted from birch bark, boasts advantages such as abundant availability and low toxicity. Due to its diverse pharmacological activities, including anti-cancer, treatment of alcoholic liver disease, anti-inflammatory, and anti-fatigue properties, it has become a hot topic in Traditional Chinese Medicine research. In drug development, betulin's diverse pharmacological activities avoid the drawbacks of a single mechanism of action and the susceptibility to drug resistance.Bet can inhibit LPS-induced inflammatory responses such as ROS production in microglial mitochondria, Nlrp3 inflammasome activation, and IL-1β secretion, and has the effect of protecting mitochondrial membrane potential.

(reference:Inhibitory effect of betulin on LPS-induced inflammation of microglia,Third Affiliated Hospital of Qiqihar Medical University) 

1. Anti-tumor and Anticancer Activity

This is the area in which betulin has been most extensively and intensively studied. It exhibits selective inhibitory and cytotoxic effects against various cancer cell lines, while exhibiting low toxicity towards normal cells.

2. Antiviral Activity

Btulin and its derivatives (especially betulic acid) have inhibitory effects against various viruses (HIV, HSV, and HCV).

3. Anti-inflammatory and Immunomodulatory Effects

Btulin can effectively inhibit the production of inflammatory factors, thereby alleviating the inflammatory response.

Potential Applications: It has potential therapeutic value for inflammatory diseases such as arthritis, dermatitis, enteritis, and atherosclerosis.

4. Antioxidant Effects

Btulin can directly scavenge free radicals, such as superoxide anions and hydroxyl radicals, and enhance the activity of antioxidant enzymes in the body, thereby protecting cells from oxidative damage. This is closely related to its anti-aging, neuroprotective, and cardiovascular protective effects.

5. Cardiovascular Protection

Lipid-Lowering and Anti-atherosclerosis Effects: Studies have shown that betulin can significantly lower total cholesterol (TC), triglyceride (TG), and low-density lipoprotein (LDL) levels in the blood. It slows the formation of atherosclerotic plaques by regulating lipid metabolism and inhibiting intravascular inflammation.

6. Skin Protection and Repair

Wound Healing: Birch bark extract has traditionally been used to treat wounds. Betulin can promote the proliferation and migration of keratinocytes and fibroblasts, accelerating the wound healing process.

1. Pharmaceutical R&D

Btulin is a star molecule in anticancer drug development. Its core advantage lies in its "selective cytotoxicity," effectively inducing apoptosis in cancer cells while minimizing damage to normal cells. It has demonstrated significant potential in preclinical studies for melanoma and leukemia. Furthermore, its anti-HIV and influenza virus activities, as well as its liver-protective and lipid-lowering properties, make it a candidate for a variety of therapeutic agents. Currently, the main challenge lies in chemically modifying its structure to address its poor water solubility and bioavailability.

2. Cosmetics and Personal Care

This is betulin's most mature application area. With its excellent antioxidant and anti-inflammatory properties, it is widely used in high-end serums, creams, and skincare products for anti-aging, soothing sensitive skin, and repairing the skin barrier. Its natural origin aligns with the "clean beauty" trend. It can also serve as a mild, natural preservative, reducing the use of chemical additives and meeting consumer demand for safe, effective products.

3. Industrial Materials

As an innovative area, Betulin Powder is being used as a green raw material for the synthesis of bio-based materials. Chemists have exploited its rigid structure and hydrophobic properties to convert it into polymer monomers for the development of biodegradable plastics, resins, and super-hydrophobic coatings. These coatings can be applied to textiles, leather, and building materials, providing environmentally friendly waterproof and antifouling solutions while reducing dependence on petrochemicals.

• High Quality: We utilize advanced purification processes to ensure high product purity, low impurity levels, and robust batch-to-batch stability, providing reliable support for your R&D and production.
• Versatile: Our high-purity betulin is an ideal raw material for pharmaceutical R&D (anti-cancer, antiviral), high-end cosmetics (anti-inflammatory, antioxidant), and functional foods. It offers a broad range of applications and can meet your cross-disciplinary development needs.
• Customizable: We offer customized product specifications, including varying purity, powder particle size, and solvent solubility, tailored to your specific application, to flexibly meet your project requirements.​​​​​​​​​​​​​​​​​​​​​

Q: Is it right for utilization?

  A: Indeed, it is totally okay for utilization when utilized as coordinated.

Q: What is the timeframe for realistic usability of it?

  A: The timeframe of realistic usability of birch bark extract is 2 years when put away in a cool and dry spot.

Q: Might it at any point be utilized in natural skincare items?

  A: Indeed, it is natural and can be utilized in the creation of natural skincare items.​​​​​​​