Emodin Powder

Emodin is an anthraquinone compound extracted primarily from traditional Chinese medicine plants such as rhubarb, knotweed, and polygonum multiflorum. As one of the main active ingredients in these herbs, it exhibits a variety of significant pharmacological effects, including laxative, antibacterial, anti-inflammatory, anti-tumor, and kidney protection.

Healthkintai is a manufacturer and supplier of Emodin Powder. With a professional R&D team and a large-scale production facility, we can provide customized services. Our emodin undergoes rigorous control from the very beginning, ensuring it's pure and natural. If you require high-quality emodin, please feel free to contact us at health@kintaibio.com.

Emodin can reduce the damage of inflammation to articular cartilage by regulating the release of proinflammatory cytokines; inhibit oxidative stress response through antioxidant mechanism, reduce the generation of reactive oxygen species, and protect chondrocytes from oxidative damage; and maintain the structure and function of articular cartilage by regulating the metabolism of cartilage extracellular matrix and inhibiting the formation of matrix-degrading enzymes; at the same time, Emodin Powder can regulate complex pathological networks through related signaling pathways, exert a protective effect on articular cartilage or chondrocytes, and thus prevent and treat osteoarthritis.

（Reference：Research progress in the pharmacological effects and mechanisms of emodin in preventing and treating osteoarthritis）

Anti-inflammatory Effects: Its active ingredients effectively inhibit the production of key inflammatory mediators such as cyclooxygenase (COX) and lipoxygenase (LOX), and regulate inflammatory signaling pathways such as NF-κB, thereby exerting significant anti-inflammatory effects.

Antibacterial Effects: It exhibits broad-spectrum inhibitory effects against a variety of Gram-positive and Gram-negative bacteria (such as Staphylococcus aureus and Streptococci). Its mechanism is to disrupt the integrity of bacterial cell walls and membranes.

Anxiety Relief: Studies have shown that rhubarb extract can exert certain sedative and anxiolytic activities by regulating GABAergic signaling pathways in the central nervous system.

Digestive Effects: It exhibits dual regulatory properties. On the one hand, anthraquinone glycosides stimulate the intestinal wall, enhance intestinal motility, and produce a laxative effect. On the other hand, components such as tannins have astringent and antidiarrheal properties and can promote bile secretion, promoting choleretic and liver protection.

Effects on Skin: With its anti-inflammatory, antibacterial and astringent properties, it is used in dermatology to treat infectious skin diseases such as acne and folliculitis, as well as inflammatory skin problems such as eczema and dermatitis.

Hepatotoxicity: This is the most concerning potential risk. Long-term or high-dose use of emodin may cause hepatocellular damage and renal tubular epithelial cell toxicity, posing a risk of drug-induced liver injury and renal impairment.

Intestinal lesions: Long-term abuse of laxatives containing emodin (and other anthraquinones) can lead to melanosis coli, characterized by pigmentation of the colonic mucosa. While this condition is generally considered reversible, it is considered a warning sign of abuse. In severe cases, further damage to the enteric nervous system may occur, leading to purgative colon, manifested by worsening constipation and colonic motility failure.

Reproductive toxicity: Some studies suggest that Emodin Powder may have certain effects on the reproductive system, demonstrating potential embryotoxicity and genotoxicity. Therefore, pregnant women and those attempting pregnancy should avoid its use.

Drug interactions: As a biologically active ingredient, it may interact with other drugs by affecting hepatic drug enzymes (such as CYP450 enzyme system) or drug transporters, thereby affecting the latter's metabolism and efficacy.

1. Traditional and Modern Clinical Medicine

As a classic remedy for constipation caused by excess heat and abdominal pain due to stagnation, its anthraquinone glycosides are the primary active ingredients responsible for its laxative effect.

Due to their significant anti-tumor, antibacterial, and anti-fibrotic (such as liver and kidney fibrosis) activities, monomeric components such as rhubarb and rhein have become important lead compounds in the development of anticancer drugs, antibiotics, and targeted therapies.

2. Daily Chemicals and Cosmetics

• Skin Care: Utilizing the antibacterial and anti-inflammatory properties of rhubarb extract, it is being used in the development of functional skin care products for the treatment of acne, dermatitis, and other problems.
• Oral Care: Added to toothpaste and mouthwash, it can aid in the prevention and treatment of oral inflammation such as gingivitis and periodontitis, exerting its heat-clearing and fire-purging effects.
• Hair Care: Research is exploring its potential use in promoting hair growth or treating seborrheic dermatitis of the scalp.

3. Food and Health Products

• Natural Pigments: Anthraquinone pigments contained in rhubarb roots can be used as natural dyes for food coloring.
• Health Food: Rhubarb is sometimes used to develop health products with laxative and lipid-lowering properties. However, due to its strong medicinal properties, it should be used with extreme caution.

1. Authoritative International Certifications
Kintai's production facilities strictly adhere to cGMP (Current Good Manufacturing Practice) and have achieved multiple international certifications, including ISO9001 and ISO22000. Core products have also successfully obtained DMF filings from the US FDA and CEP certifications from the EU EDQM. These prestigious certifications demonstrate that Kintai's emodin meets the most stringent global pharmaceutical regulatory requirements for purity, stability, and consistency.

2. Scientific Quality Control
We are committed to providing high-purity, highly active Emodin Powder that exceed pharmacopoeial standards. Applying cutting-edge analytical techniques such as chromatographic fingerprinting and high-performance liquid chromatography, we conduct precise quality control throughout the entire process, from raw materials to finished product, ensuring the stable content of key active ingredients like emodin and strictly controlling impurities such as heavy metals, pesticide residues, and solvent residues below specified limits. This unwavering commitment to quality ensures that you receive highly consistent, high-performance raw materials from batch to batch during R&D and production, guaranteeing the efficacy and safety of your end products from the source.

3. Customized Solutions
Kintai deeply understands the diverse needs of innovative R&D. We not only offer a stable supply of a full range of standard specifications,  but also possess robust customization capabilities. Whether adjusting purity and dosage form (e.g., powder, liquid extract) to meet your specific formulation goals, optimizing processes for solubility and particle size distribution, or even providing personalized packaging and logistics solutions, our dedicated technical team will work closely with you to provide precise raw material support for your new drug development and product upgrades, creating a competitive advantage in the market.

Q1:What is emodin used for?

A1:Emodin has a wide range of biological activities, including diuretic, antibacterial, antiulcer, anti-inflammatory, anticancer and antinociceptive. 

Q2:Is emodin a laxative?

A2:Emodin (1,3,8-trihydroxy-6-methylanthraquinone) is a stimulant laxative and used to treat constipation.