Kintai Citicoline Powder Safety: GMP-Certified, USP/EP Compliant & Low-Risk

Product Details

 What Is Citicoline Powder 

Citicoline Powder is a supplement ingredient that provides choline and cytidine—vital nutrients for brain health and function.CDP-choline, which naturally occurs in the body, is key to synthesizing phosphatidylcholine, a major component of cell membranes. It participates in multiple brain-related processes, including neurotransmitter production, cell membrane repair, and the formation of brain phospholipids. Available as a dietary supplement (such as CDP-choline sodium powder), it is commonly used to support cognitive function, memory, focus, and overall brain health.Healthkintai® is a globally trusted supplier of citicoline ingredients, offering nutrition brands worldwide solutions that meet strict quality standards. Our citicoline ingredients consistently reach a purity of over 98%, complying with the USP43/NF38 monograph.

Healthkintai^® Citicoline Powder Sample packing                                                                                                 Healthkintai^® Citicoline Powder Sample 1KG

 Healthkinai® Citicoline Powder Advantages 

High Purity And Efficiency​

Our Citicoline Powder stands as a pharmaceutical-grade product boasting a minimum purity of 98%. To guarantee its exceptional quality, we employ rigorous analytical methods including HPLC (High-Performance Liquid Chromatography), GC (Gas Chromatography), and NMR (Nuclear Magnetic Resonance) spectroscopy. These advanced techniques not only confirm the high purity of the powder but also ensure optimal bioavailability, allowing for efficient absorption and utilization by the body. Moreover, such stringent testing protocols guarantee batch-to-batch consistency, providing reliable performance across all productions.​

Multi-Industry Applications​

Nutraceuticals:

Within the nutraceutical sector, our Citicoline Powder serves as a valuable ingredient. It is widely utilized to enhance cognitive function, offering support for memory retention and boosting brain energy metabolism. This makes it a popular choice in supplements designed to help individuals maintain mental clarity and focus, whether they are students, professionals, or elderly people looking to preserve cognitive abilities.​

Pharmaceuticals:

In the pharmaceutical field, the powder plays a significant role. It aids in stroke recovery by promoting neural repair and regeneration. Additionally, it exhibits neuroprotective properties, helping to safeguard nerve cells from damage. It is also employed in the treatment of various neurodegenerative diseases such as Alzheimer's and Parkinson's, contributing to the alleviation of symptoms and the slowing of disease progression.​

Research:

For research purposes, our Citicoline Powder is an invaluable tool. It facilitates in-depth studies on neuroplasticity, exploring how the brain can reorganize and adapt. It also supports investigations into mitochondrial function, which is crucial for energy production in brain cells, and cholinergic pathways, which are involved in numerous brain functions including learning and memory.​

Strict Quality Control​

Our Citicoline Powder is manufactured in a GMP (Good Manufacturing Practice) certified facility, ensuring that all production processes adhere to the highest industry standards. We maintain full traceability throughout the entire production chain, from the sourcing of raw materials to the final packaging of the product. Each batch undergoes comprehensive testing, covering aspects such as COA (Certificate of Analysis), MSDS (Material Safety Data Sheet), and checks for heavy metals, residual solvents, and microbial contaminants. These tests are conducted in strict compliance with global regulatory standards, ensuring the safety, purity, and efficacy of our product.

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 The Synthesis Process Of Citicoline 

Citicoline Powder is produced via a multi-step synthetic process to ensure pharmaceutical-grade quality, with strict controls for purity, stability, and bioactivity. Here’s a condensed breakdown of the workflow:​

1. Chemical Synthesis​

The core CDP-choline structure is formed through two key steps:​

Cytidine Phosphorylation: Cytidine reacts with POCl₃ in anhydrous solvents (e.g., acetonitrile) under controlled low temperatures (0–5°C) and acidic pH (2–3) to form CMP, achieving >90% purity.​

Choline Activation and Coupling: Choline is phosphorylated to phosphocholine, then coupled with CMP via enzymatic (CDP-choline synthase) or chemical reactions (e.g., using dicyclohexylcarbodiimide) in neutral pH (7–8) at 25–30°C, yielding crude Citicoline.​

2. Purification​

Two-stage refining ensures ≥98% purity:​

Crystallization: Crude Citicoline is recrystallized in ethanol/water (70:30 v/v), heated to 60–70°C, then cooled to 5–10°C to form pure crystals, reducing impurities to <5%.​

Chromatography: Further purified via ion exchange (removing charged impurities) and HPLC (reverse-phase C18 column) to eliminate residual intermediates.​

3. Drying and Micronization​

Drying: Purified solution is dried via spray drying (120–140°C inlet, <10s residence time) for large batches, or lyophilization (-40°C freeze-drying) for low-moisture (<0.5%) products.​

Micronization: Jet milling reduces particles to 5–20μm, enhancing solubility and bioavailability.​

4. Quality Control and Packaging​

Testing: Each batch undergoes HPLC (≥98% purity), NMR (structural confirmation), and screening for heavy metals (<10ppm), residual solvents (<500ppm), and microbes (<10³ CFU/g) per USP/EP standards.​

Compliance: Produced in ISO/GMP facilities with full traceability. Packaged in moisture/light-resistant materials (aluminum-lined bags or amber glass) with desiccants, ensuring 36-month shelf life at 2–8°C.​

This process ensures Citicoline Powder meets strict standards for pharmaceuticals, nutraceuticals, and research use.

 Citicoline Powder COA 

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 Citicoline Powder Benefits 

1. Enhance Cognitive Function and Boost Brain Vitality​

As a key source of choline and cytidine, Citicoline Powder promotes the synthesis of the neurotransmitter acetylcholine, which is crucial for maintaining memory, attention, and learning ability. Studies have shown that supplementing with Citicoline can improve information processing speed in people with cognitive decline, while also helping healthy individuals enhance task focus—making it particularly suitable for high-pressure workers or students.​

2. Protect Nerve Cells and Delay Brain Damage​

Its core component, CDP-choline, acts as a precursor for cell membrane phospholipids (such as phosphatidylcholine), enabling it to repair damaged nerve cell membranes and enhance cellular stability. Additionally, it exerts neuroprotective effects by inhibiting free radical production and reducing inflammatory responses. During stroke recovery and auxiliary treatment of traumatic brain injury, it can lower the risk of neurological deterioration, and also has the potential to slow the progression of neurodegenerative diseases like Alzheimer's and Parkinson's.​

3. Optimize Brain Metabolism and Support Energy Supply​

Citicoline stimulates the production of ATP (adenosine triphosphate) in brain cells, improving energy metabolism efficiency to provide sufficient power for brain activities. It also enhances cerebral microcirculation and increases cerebral blood flow, ensuring efficient delivery of oxygen and nutrients, thereby alleviating symptoms such as dizziness and distracted attention caused by brain fatigue.​

4. Wide Range of Applications, Covering Prevention and Auxiliary Treatment​

In the nutraceutical field, it can serve as a daily cognitive health supplement; in the pharmaceutical sector, it supports stroke rehabilitation and the treatment of neurodegenerative diseases; in research, it provides reliable raw materials for studies on neuroplasticity, mitochondrial function, etc.—achieving multi-scenario coverage from health maintenance to disease intervention.​

5. High Purity Ensures Safety, Suitable for Long-Term Use​

Citicoline Powder produced through strict processes has a purity of ≥98% and undergoes multi-dimensional testing such as HPLC and NMR. Contaminants like residual solvents, heavy metals, and microbes are controlled within USP/EP standards. Its composition is consistent with naturally occurring CDP-choline in the human body, featuring high biocompatibility. Proper long-term supplementation is unlikely to cause adverse reactions, with its safety widely verified.​

 Citicoline Powder Applications 

1. Nutraceutical Supplements for Cognitive Health​

Citicoline Powder is extensively integrated into over-the-counter cognitive support supplements, catering to individuals aiming to enhance daily mental performance. It is formulated into various forms such as capsules, powders, and functional beverages to support memory retention, focus, and mental clarity. This makes it particularly appealing to students, professionals, and older adults striving to maintain cognitive vitality. Its capacity to boost acetylcholine levels solidifies its position as a key ingredient in "brain health" formulations.​

2. Pharmaceutical Adjuvants in Neurological Care​

Within clinical environments, it functions as an auxiliary therapeutic agent in the management of neurological conditions. When prescribed alongside standard treatments, it aids in stroke recovery by facilitating neural membrane repair and mitigating post-injury inflammation. Additionally, it is employed in supportive care for neurodegenerative diseases like Alzheimer’s and Parkinson’s, contributing to the slowing of cognitive decline and the preservation of motor function.​

3. Research Tools in Neuroscience Studies​

Citicoline Powder holds significant value in academic and pharmaceutical research, serving as a critical tool to advance investigations into brain physiology. It is utilized to explore neuroplasticity (the brain’s ability to reorganize), mitochondrial energy metabolism, and the regulation of cholinergic pathways. Researchers depend on its high purity to conduct both in vitro and in vivo experiments, yielding insights that inform potential treatments for cognitive disorders.​

4. Sports Nutrition for Mental Stamina​

In the sports nutrition sector, it is incorporated into formulations specifically designed to counteract mental fatigue during intense physical exertion. By supporting brain energy metabolism and enhancing blood flow, it helps athletes sustain focus, decision-making capabilities, and reaction speed—factors that are crucial for optimal performance in endurance sports and high-precision activities.​

5. Ophthalmic Health Formulations​

Owing to its ability to improve ocular blood circulation and support Optic nerve metabolism, Citicoline Powder is utilized in specialized supplements and topical preparations for eye health. It plays a role in managing conditions such as glaucoma by protecting retinal ganglion cells and preserving visual function, often as an integral component of a comprehensive eye care regimen.

 Kintai Citicoline Powder Safety 

1. Stringent Manufacturing Standards Ensure Baseline Safety​

Kintai Citicoline Powder is produced in GMP-certified facilities compliant with ISO 9001 standards, where strict process controls (e.g., controlled temperature/humidity during synthesis, aseptic purification) minimize contamination risks. Full traceability from raw material sourcing to final packaging allows for rapid identification and resolution of any quality deviations, forming a foundational safety guarantee.​

2. Rigorous Purity and Contaminant Testing​

Each batch undergoes comprehensive analytical testing, including HPLC (to verify ≥98% purity), NMR (structural confirmation), and screening for heavy metals (lead, arsenic, mercury ≤10ppm), residual solvents (<500ppm), and microbial contaminants (total aerobic count <10³ CFU/g). These tests align with USP43/NF38 and EP monographs, ensuring freedom from harmful impurities.​

3. Compliance with Global Regulatory Standards​

Kintai Citicoline Powder meets safety requirements for both dietary supplements and pharmaceutical ingredients, with certifications supporting market access in regions like the EU, U.S., and Asia. Its compliance with international pharmacopeias (USP/EP) demonstrates adherence to universally recognized safety benchmarks, facilitating trust across global markets.​

4. Excellent Biocompatibility and Low Adverse Reaction Risk​

As a synthetic form of endogenously occurring CDP-choline, the powder exhibits high biocompatibility with the human body. Clinical and post-market data show minimal adverse effects (e.g., rare mild gastrointestinal discomfort at high doses), with no reported severe toxicity. This makes it suitable for long-term use under recommended dosages.​

5. Clear Safety Guidelines for Diverse Populations​

Kintai provides detailed safety guidelines, including dosage recommendations (typically 200–1000mg/day for adults) and precautions for sensitive groups (e.g., consult a physician before use in pregnancy, breastfeeding, or with pre-existing neurological conditions). Such transparency helps users and formulators mitigate risks effectively.​

 Why Choose Citicoline Powder By Healthkintai®? 

1. We promise that our raw materials are naturally grown without any additives.
2. We provide customized extraction solutions to produce Citicoline Powder in various specifications tailored to your requirements.
3. Our production facilities hold internationally recognized certifications including GMP, ISO 9001, ISO 22000, HACCP, KOSHER, and HALAL, guaranteeing the highest standards for your peace of mind.

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 OEM and ODM Services 

KINTAI is a professional Citicoline Powder manufacturer and supplier. We offer OEM and ODM administrations to take care of the particular necessities and prerequisites of our clients. Our group of specialists can foster modified items and offer coordinated support arrangements.

Our Certifications

About KINTAI

KINTAI is a leading manufacturer and supplier of Citicoline Powder. We have a cutting-edge innovative workplace, creation offices, and hardware. Our obligation to quality is clear through our broad scope of licenses and confirmations. We offer customized products, providing integrated solutions and fast delivery with secure packaging.

 KINTAI's Procession 

 Packing And Shipping