Pure Luteolin

Healthkintai^® stands out as a leading producer of premium Pure Luteolin (CAS: 491-70-3). Leveraging state-of-the-art extraction and purification technologies, we offer pharmaceutical-grade products, preserving luteolin in its most bioactive form with enhanced water-dispersibility. This unique feature enables excellent absorption and efficacy across diverse applications. Our stringent quality control processes ensure consistent purity and potency, positioning our 98%Luteolin as a trustworthy option for industries in search of high-standard natural ingredients. Whether applied in functional beverages, dietary supplements, pharmaceuticals, or cosmetics, the remarkable water solubility and bioavailability of our product facilitate the creation of top-notch formulations. 

1. Raw Material Pretreatment

We carefully select plant materials rich in luteolin, such as chrysanthemums, celery, and thyme. These materials undergo rigorous cleaning to remove sediment and impurities. Subsequently, they are either dried at low temperatures or air-dried naturally, ensuring the moisture content is ≤8%. The dried materials are then ultra-finely ground to a particle size of 60-80 mesh, increasing the surface area and enhancing the efficiency of subsequent extraction processes.

2. High-Efficiency Extraction Process

• Solvent Selection: Food-grade ethanol with a concentration of 80% is used as the extraction solvent, striking a balance between safety and extraction efficiency.
• Thermal Reflux Extraction: The extraction is carried out under a gentle boiling state (temperature: 70-80°C) for 2-3 hours. The solvent status is monitored dynamically to prevent component degradation caused by violent boiling.
• Ultrasonic-Assisted Technology: Simultaneously, ultrasonic treatment (frequency: 40kHz) is employed. The cavitation effect of ultrasonic waves breaks the cell walls, reducing the extraction time to just 1 hour and increasing the yield by 15-20%.

3. Crude Extract Purification

• Concentration and Degreasing: The extraction solution is concentrated under reduced pressure to 1/5 of its original volume, followed by extraction with petroleum ether three times to remove lipophilic impurities.
• Column Chromatography Refinement: AB-8 macroporous resin is used for adsorption. First, deionized water is applied to wash away polysaccharides, and then 95% ethanol is used for gradient elution. The luteolin-enriched fractions are collected.
• Crystallization Purification: The eluate is concentrated and recrystallized using a methanol-water (7:3) system, yielding pale yellow needle-like crystals with a purity of ≥98%.

4. Drying and Packaging

The purified wet luteolin is vacuum freeze-dried (-40°C, 24h) to remove residual solvents, ensuring the moisture content is <0.5%. The finished product is packaged in nitrogen-filled aluminum foil bags and stored in a cool, dry environment away from light, complying with GMP standards.​​​​​​​

Luteolin is a natural flavonoid compound with multiple benefits for vision protection. Its core role lies in its powerful antioxidant and anti-inflammatory properties, which effectively neutralize free radicals in the eye, reduce oxidative stress, and inhibit inflammatory responses. Specifically, it helps slow the progression of age-related macular degeneration (AMD) and inhibit abnormal angiogenesis; it can prevent cataracts and protect lens proteins from oxidative damage; and it can also alleviate vascular inflammation and leakage in diabetic retinopathy. Furthermore, it has a protective effect on the optic nerve, may help slow the progression of glaucoma, and help alleviate visual fatigue and dry eye. 

• Anti-inflammatory: Pure Luteolin can inhibit the production of a variety of inflammatory factors, reduce the activity of inflammatory factors transcription regulators, and thus play an anti-inflammatory role.
• Anti-tumor: Luteolin can inhibit the activity of certain kinases in cells and the tissue cell cycle, inhibit the proliferation and angiogenesis of tumor cells, and thus play an anti-tumor role.
• Antibacterial, antiviral: It has an inhibitory effect on a variety of bacteria and viruses, such as staphylococcus aureus, Escherichia coli, herpes simplex virus, poliovirus and so on.
• Antioxidant: Luteolin can be used as a reducing agent to undergo oxidation reactions and enhance the activity of antioxidant systems in organisms.​​​​​​​

1. High Purity and High Content of Active Ingredients
Kintai uses advanced extraction and purification processes to ensure the extremely high purity of its luteolin products (over 98%). This enhanced biological activity allows for more precise dosage control during R&D and application, significantly improving its effectiveness and reliability in high-value-added applications such as pharmaceuticals and health supplements.

2. Meeting the Diverse Application Needs
With its superior product quality, Kintai's Pure luteolin meets the demanding requirements of various industries, including pharmaceuticals, health supplements, and cosmetics. The company offers a variety of specifications, providing a solid foundation for customer success in diverse application scenarios.

3. Strict Quality Control
Kintai adheres to international standards, and its production lines hold multiple certifications, including GMP, ISO9001, HACCP, and HALAL. This represents a comprehensive, traceable quality management system, from raw material sourcing and production to finished product delivery. Each batch of products undergoes rigorous testing to ensure its purity, safety, consistency and contamination-free, providing customers with absolute quality assurance and compliance, making us a trustworthy long-term partner.

1.Q:Does luteolin raise blood pressure?

   A:Our novel findings revealed that luteolin lowered hypertension via inhibiting NF-κB-mediated inflammation and PI3K/Akt signaling pathway in the PVN.

2.Q:Does luteolin make you gain weight?

   A:It reportedly has antitumor, anti-inflammatory, and anti-obesity effects 

3.Q:Can I request a sample before placing a bulk order?

   A:Yes, we encourage clients to request samples for testing and evaluation.

4.Q:Do you offer documentation for regulatory compliance?

   A:KINTAI provides all necessary documentation, including certificates and regulatory information, to ensure compliance with global standards.