Pure Luteolin

Product Details

Xi'an Kintaihealth® stands out as a leading producer of premium Luteolin (CAS: 491-70-3). Leveraging state-of-the-art extraction and purification technologies, we offer pharmaceutical-grade products, preserving luteolin in its most bioactive form with enhanced water-dispersibility. This unique feature enables excellent absorption and efficacy across diverse applications. Our stringent quality control processes ensure consistent purity and potency, positioning our Luteolin as a trustworthy option for industries in search of high-standard natural ingredients. Whether applied in functional beverages, dietary supplements, pharmaceuticals, or cosmetics, the remarkable water solubility and bioavailability of our product facilitate the creation of top-notch formulations.

                                 What is Pure Luteolin？                               

Pure Luteolin is a kind of natural flavonoid, widely existing in a variety of plants, has a variety of pharmacological activities and clinical application value. Luteolin can inhibit the activation of mast cells and microglia, reduce the release of pro-inflammatory factors and other substances, so luteolin has antioxidant, anti-inflammatory, anti-tumor, antibacterial, neuroprotective and improve the attention and social ability of autistic children.

                             Advantages of Kintai Luteolin                                

High Potency & Clinical Efficacy

Kintai's Luteolin (CAS: 491 - 70 - 3) offers pharmaceutical - grade purity (≥98% by HPLC), enhanced with advanced processing techniques for improved bioactivity and water - dispersibility. Clinically validated for:

· Powerful anti - inflammatory effects: Significantly reduces pro - inflammatory cytokines (TNF - α reduction by ≥40% in in - vitro studies).

· Cancer preventive properties: Exhibits anti - proliferative effects on cancer cells, inhibiting tumor growth pathways 1.

· Neuroprotective benefits: Protects neurons from oxidative stress, improving cognitive function in pre - clinical models.

· 200% higher bioavailability: Compared to standard luteolin, due to our unique formulation technology.

Multi - Industry Applications

· Functional Foods: Added to antioxidant - rich snacks (50 - 150mg/kg) and anti - inflammatory beverages (0.1 - 0.3g/L).

· Pharmaceuticals: Used in oral capsules for chronic inflammation management (200 - 400mg/day) and topical ointments for skin disorders (2 - 5%).

· Beverages: Fortifies green teas and juices with antioxidant properties (0.05 - 0.2g/L).

· Cosmetics: Incorporated into anti - acne creams (1 - 3%) and anti - wrinkle serums for skin rejuvenation.

Strict Quality Control

· Purity Assurance: HPLC - verified ≥98% purity, with heavy metals (Pb≤1ppm, As≤0.5ppm) and microbial limits (≤100CFU/g).

· Stability: Stable crystalline form with a shelf life of 36 months under 25℃/60% RH conditions.

· Compliance: Manufactured in FDA - registered, GMP - certified facilities, compliant with ISO 22000 and HACCP standards.

                KinTai Natural Extraction Process of Luteolin                      

1. Raw Material Pretreatment

We carefully select plant materials rich in luteolin, such as chrysanthemums, celery, and thyme. These materials undergo rigorous cleaning to remove sediment and impurities. Subsequently, they are either dried at low temperatures or air-dried naturally, ensuring the moisture content is ≤8%. The dried materials are then ultra-finely ground to a particle size of 60-80 mesh, increasing the surface area and enhancing the efficiency of subsequent extraction processes.

2. High-Efficiency Extraction Process

Solvent Selection: Food-grade ethanol with a concentration of 80% is used as the extraction solvent, striking a balance between safety and extraction efficiency.
Thermal Reflux Extraction: The extraction is carried out under a gentle boiling state (temperature: 70-80°C) for 2-3 hours. The solvent status is monitored dynamically to prevent component degradation caused by violent boiling.
Ultrasonic-Assisted Technology: Simultaneously, ultrasonic treatment (frequency: 40kHz) is employed. The cavitation effect of ultrasonic waves breaks the cell walls, reducing the extraction time to just 1 hour and increasing the yield by 15-20%.

3. Crude Extract Purification

Concentration and Degreasing: The extraction solution is concentrated under reduced pressure to 1/5 of its original volume, followed by extraction with petroleum ether three times to remove lipophilic impurities.
Column Chromatography Refinement: AB-8 macroporous resin is used for adsorption. First, deionized water is applied to wash away polysaccharides, and then 95% ethanol is used for gradient elution. The luteolin-enriched fractions are collected.
Crystallization Purification: The eluate is concentrated and recrystallized using a methanol-water (7:3) system, yielding pale yellow needle-like crystals with a purity of ≥98%.

4. Drying and Packaging

The purified wet luteolin is vacuum freeze-dried (-40°C, 24h) to remove residual solvents, ensuring the moisture content is <0.5%. The finished product is packaged in nitrogen-filled aluminum foil bags and stored in a cool, dry environment away from light, complying with GMP standards.

5. Environmental Protection Treatment

Production wastewater first goes through grid pretreatment and then enters an equalization tank for homogenization. Coagulant is added to remove suspended solids, followed by an anaerobic-aerobic biological treatment process to degrade organic pollutants. The final effluent has a COD of ≤50mg/L, meeting national discharge standards.

JinTai Company combines optimized traditional processes with innovative technologies to achieve efficient and eco-friendly luteolin production. Our products are widely used in the pharmaceutical, health supplement, and functional food industries.

                                         Functions of Pure Luteolin                                           

1. Anti-inflammatory: Pure Luteolin can inhibit the production of a variety of inflammatory factors, reduce the activity of inflammatory factors transcription regulators, and thus play an anti-inflammatory role.
2. Anti-tumor: Luteolin can inhibit the activity of certain kinases in cells and the tissue cell cycle, inhibit the proliferation and angiogenesis of tumor cells, and thus play an anti-tumor role.
3. Antibacterial, antiviral: It has an inhibitory effect on a variety of bacteria and viruses, such as staphylococcus aureus, Escherichia coli, herpes simplex virus, poliovirus and so on.
4. Antioxidant: Luteolin can be used as a reducing agent to undergo oxidation reactions and enhance the activity of antioxidant systems in organisms.

                                               Application Fields                                       

Pure Luteolin has a wide range of clinical applications, mainly used in:
Cough and expectorant: By suppressing chronic airway inflammation and reducing airway reactivity, luteolin can effectively relieve cough and expectorant symptoms.
Anti-inflammatory: Used to treat a variety of inflammatory diseases, such as COPD, bronchial asthma, chronic pharyngitis, allergic rhinitis and so on.
Treatment of cardiovascular disease: By inhibiting the proliferation of vascular smooth muscle cells and DNA synthesis, luteolin helps protect the health of the cardiovascular system.
Treatment of other diseases: For SARS, hepatitis, amyotrophic lateral sclerosis, etc., luteolin has also shown a certain therapeutic effect.

                                     Safety of KINTAI’S Luteolin Powder                                 

Toxicological Considerations

KINTAI’s Luteolin Powder has demonstrated a favorable toxicological profile, indicating its safety for various applications. In pre - clinical animal studies, the oral LD₅₀ value of our luteolin powder was found to be well above 2000 mg/kg body weight. This high LD₅₀ value strongly suggests that, under normal usage conditions, the risk of severe acute toxicity is extremely low.

Numerous human studies and long - term applications within the recommended dosage range have also failed to report any significant adverse effects. Luteolin, a flavonoid compound naturally present in many dietary plants, has been widely studied for its potential health benefits, such as anti - inflammatory and antioxidant properties. However, it is important to note that while chronic exposure to luteolin is generally considered safe, individuals with specific sensitivities may experience mild discomfort when exposed to extremely high concentrations. For instance, some sensitive individuals might encounter symptoms like mild digestive disturbances, including stomachache, or a feeling of nausea. To ensure the utmost safety of consumers, KINTAI conducts continuous and in - depth toxicity tests. These tests cover acute, sub - acute, and chronic toxicity evaluations, enabling us to thoroughly understand the potential risks associated with our luteolin powder and to ensure strict compliance with all relevant safety regulations and guidelines.

Quality Control & Safety Certifications

Our Luteolin Powder is manufactured in state - of - the - art facilities that adhere strictly to Good Manufacturing Practice (GMP) standards. This commitment to GMP ensures consistent production quality and safety. Through advanced High - Performance Liquid Chromatography (HPLC) analysis, we accurately verify that each batch of our luteolin powder maintains a minimum purity level of ≥98%. This high - purity standard guarantees the efficacy and reliability of our product.

In addition to purity testing, KINTAI implements a comprehensive quality control system for safety - related parameters. Every batch undergoes stringent testing for heavy metals, with strict limits set at Pb ≤2ppm and As ≤1ppm, far below the internationally accepted maximum allowable levels. Residual solvents, which could potentially pose health risks if present in excessive amounts, are also carefully analyzed using gas chromatography techniques to ensure they are within safe limits. Microbial safety is another crucial aspect of our quality control. We perform tests for common pathogens such as E. coli, Salmonella, and Staphylococcus aureus to ensure that our product is free from harmful microorganisms.

To provide complete transparency and assurance to our customers, a detailed Certificate of Analysis (COA) and Material Safety Data Sheet (MSDS) are provided with each batch. These documents comprehensively detail the product’s composition, purity, safety data, and handling instructions. Our products also comply with international safety benchmarks established by authoritative organizations such as the US Food and Drug Administration (FDA), the European Food Safety Authority (EFSA), and the World Health Organization (WHO), further validating their safety and quality.

Safety Warnings & Limitations

· Contraindications: As with many natural compounds, there is currently insufficient data on the safety of luteolin powder during pregnancy and lactation. Therefore, pregnant or lactating women are strongly advised not to use our Luteolin Powder without first consulting a healthcare professional. The physiological changes during these periods may affect how the body processes luteolin, and further research is needed to fully understand any potential risks to the mother and the developing fetus or infant.

· Adverse Reactions: Although rare, ingesting excessive amounts of luteolin powder may lead to adverse reactions. The most common mild side effects include gastrointestinal discomfort, such as indigestion or abdominal pain. In some cases, individuals may also experience headaches or dizziness. If any discomfort or unexpected adverse reactions occur during the use of our luteolin powder, immediate discontinuation of use is recommended, and users should seek medical advice if symptoms persist or worsen.

· Handling: Luteolin powder is a fine particulate substance, and direct inhalation should be strictly avoided to prevent potential respiratory irritation. When handling the powder, it is recommended to work in well - ventilated areas or use appropriate respiratory protection equipment, such as masks. To maintain the product’s quality and stability, store it in a cool, dry place, away from direct sunlight and heat sources. Exposure to high temperatures, humidity, or sunlight can potentially alter the chemical properties of luteolin, reducing its efficacy and safety.

                Why Choose Luteolin Powder by Kintaihealth^®?                    

1. We promise that our raw materials are naturally grown without any additives.
2. We provide customized extraction solutions to produce Luteolinpowder in various specifications tailored to your requirements.
3. Our production facilities hold internationally recognized certifications including GMP, ISO 9001, ISO 22000, HACCP, KOSHER, and HALAL, guaranteeing the highest standards for your peace of mind.

                                    OEM and ODM Services                                         

KINTAI takes pride in offering OEM and ODM services, allowing clients to customize products based on their unique specifications. Our experienced team collaborates closely with clients to develop tailor-made solutions, ensuring the final product meets their expectations. For more information, please contact us at info@kintaibio.com.

FAQ

1. Can I request a sample before placing a bulk order?

   • Yes, we encourage clients to request samples for testing and evaluation.

2. What is the lead time for bulk orders?

   • Our efficient production process enables us to provide fast delivery, with lead times varying based on order volume.

3. Do you offer documentation for regulatory compliance?

   • KINTAI provides all necessary documentation, including certificates and regulatory information, to ensure compliance with global standards.

Certifications

Advantage Of KINTAI

KINTAI is a professional manufacturer and supplier of luteolin powder, We have our own research and development center, production base, and state-of-the-art equipment. With multiple patents and certifications, we guarantee the highest quality and safety of our products. We provide comprehensive OEM and ODM services, ensuring customized products and integrated solutions. With fast delivery and secure packaging, we are your trusted partner in choosing your product.

Parcel and Shipping

1> 1KG/bag, 10KG/carton, 25kg/drum
2> By Express: Door to door; DHL/FEDEX/EMS; 3-4DAYS; Suitable for under 50kg; high cost; easy to pick up the goods
3> By Air: Airport to Airport; 4-5 days; Suitable for more than 50kg; high cost; professional broker needed
4> By Sea: Port to Port; 15-30days; Suitable for more than 500kg; Low cost; professional broker needed

KINTAI's  pure luteolin stands as a testament to our commitment to quality and excellence. Our integrated service solutions, coupled with fast delivery and secure packaging, make us the preferred choice for professional buyers and global dealers. For inquiries or to request it, contact us at info@kintaibio.com. Trust KINTAI for premium botanical extracts that elevate your products and exceed expectations.

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