15%Water-Soluble Mangiferin in Mango

Best Mango Leaf Extract Manufacturer

Mangiferin is a ketosyl glycoside extracted from plants mango leaves. Studies have shown that it possesses excellent anti-inflammatory, antioxidant, neuroprotective, and metabolic-improving biological activities. Therefore, it has attracted widespread attention in the pharmaceutical, health product, and food industries and is a natural product with promising development prospects.

Healthkintai^® is one of the most experienced manufacturers and suppliers of 15%-98% Mangiferin solubility in China. Please feel free to wholesale 15%Water-Soluble Mangiferin in mango for sale here from our factory. For price consultation, contact us at health@kintaibio.com.

KINTAI Water Soluble Mangiferin Breakthroughs

The practical applications of mango leaf extract are severely limited by its physicochemical properties. On the one hand, due to the presence of C-glycosidic bonds, its water solubility is extremely low; on the other hand, its insufficient lipophilicity (log P = -0.65) prevents it from effectively penetrating cell membranes, ultimately resulting in an oral bioavailability of only 1.2%. To overcome this predicament, developing innovative delivery systems and formulation technologies is crucial.

To address the bottlenecks in the application of mangiferin in beverage systems—low solubility and pH sensitivity—Healthkintai^® launched 15% water-soluble mangiferin in Mango in 2025. This product is a highly soluble functional ingredient extracted using an ethanol-water system, which can serve as a caffeine alternative, injecting clean energy into products.

• Salt treatment technology:

Mangiferin monosodium salt (MLES) increases water solubility from 0.111 mg/mL to 10 mg/mL (90 times increase). Human pharmacokinetic studies have confirmed that the AUC₀₋₂₄h of MLES is 2.44 times higher than that of mango leaf extract (MLE60) (p=0.0029)

• Citrate enhancement system:

The premixed system of mangiferin: citric acid = 1:3 (molar ratio) can prevent precipitation. In the pH range of 3-8, the turbidity value is <5 NTU (Nephelometric Turbidity Unit), ensuring the optical stability of the product during the shelf life.​​​​​​​

• Cyclodextrin inclusion:

β-cyclodextrin (β-CD) inclusion reduces the heat of solution from -28.4 kJ/mol to -16.2 kJ/mol, indicating improved thermodynamic stability. The inclusion complex remained crystal-free for 6 months in an accelerated test (40℃/75% RH).

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KINTAI Mangiferin Patent Certs

Adventages of Water Soluble Mangiferin

1. Enhanced Bioavailability

Water-soluble technology fundamentally solves the problem of mangiferin absorption difficulties. For example, human studies of mangiferin monosodium salt (MLES) show that its in vivo bioavailability (AUC) is 2.44 times that of ordinary mangiferin extract. This means that the active ingredient can be absorbed and utilized by the human body more efficiently, thus ensuring its full physiological function.

2. Solubility and Stability

Through stabilization treatments such as the citric acid enhancement system, it can withstand different pH environments (3-8) and maintain a clear and transparent solution (turbidity <5 NTU) throughout the product's shelf life, effectively solving the problems of precipitation and separation.

3. Upgraded Market Value

The breakthrough in solubility allows mangiferin's excellent antioxidant, anti-inflammatory, metabolic regulation, and neuroprotective activities to be realized in a wider range of product forms. mangiferin can not only replace caffeine as a "clean label" energy ingredient, but also open up new application scenarios for it in high-efficiency health products, thus greatly enhancing its market value.

Mangiferin Health Benefits​

1. Powerful Antioxidant and Anti-inflammatory Effects

Mangiferin can directly neutralize free radicals in the body and upregulate the body's own antioxidant defense system (such as the Nrf2 pathway), thereby reducing oxidative stress damage. Simultaneously, by inhibiting key inflammatory signaling pathways such as NF-κB, it reduces the production of inflammatory factors at the source, showing positive intervention potential for chronic inflammation-related diseases (such as metabolic syndrome and arthritis).​​​​​​​

2. Metabolic Regulation and Liver Protection

Studies have shown that mangiferin has a significant effect on improving glucose and lipid metabolism. In terms of blood glucose regulation, mango leaf extract can effectively inhibit intestinal α-glucosidase activity, delay carbohydrate digestion and absorption, and promote glucose utilization in peripheral tissues by improving insulin sensitivity. In the field of lipid metabolism, mangiferin can reduce hepatic fat deposition, inhibit lipid peroxidation, and alleviate liver inflammation and fibrosis, demonstrating a clear protective effect against liver damage such as non-alcoholic fatty liver disease. Its multi-target mechanism of action makes it a potential natural compound for the prevention and treatment of metabolic diseases.

3. Anti-Obesity and Gut Health

Mangiferin exerts its anti-obesity effects through multiple pathways. Regarding gut health, mango leaf extract effectively regulates the gut microbiota structure, promoting the proliferation of beneficial bacteria such as Bifidobacteria and Lactobacillus, inhibiting the growth of pathogenic bacteria, and improving intestinal barrier function. At the energy metabolism level, mangiferin activates the AMPK signaling pathway, promoting fatty acid oxidation and energy consumption, accelerating fat breakdown, and simultaneously inhibiting fat synthesis. This mechanism of action, addressing both gut microbiota and energy metabolism balance, makes mangiferin effective in controlling weight and reducing body fat accumulation, providing a new natural solution for obesity prevention and treatment.

Mangiferin Uses

1.Mangiferin Supplements

Mangiferin in Mango is a natural anti-inflammatory, antioxidant, and metabolic regulator. In the pharmaceutical field, its formulations are extensively studied for the treatment of metabolic syndromes (such as diabetes and fatty liver), neurodegenerative diseases (such as Alzheimer's disease), and chronic inflammation. Furthermore, it is widely developed as a dietary supplement and health food for boosting immunity, protecting the liver, and delaying aging.（Common forms include mangiferin capsules and tablets.）

2.Functional Foods and Beverages

With the successful commercialization of water-soluble mangiferin, it has become an ideal additive for functional beverages and foods. It dissolves easily in aqueous systems and is used to manufacture energy drinks that combat fatigue and provide a boost, as well as juices, dairy products, and solid beverages with health claims. It can also serve as a "clean label" caffeine alternative, meeting consumers' demand for natural and healthy ingredients.

3. Personal Care and Cosmetics

In the cosmetics field, mangiferin's powerful antioxidant capabilities make it a high-quality natural skincare ingredient. It is added to serums, creams, and other products for anti-photoaging, reducing UV damage, whitening and fading dark spots, and anti-wrinkle effects. Its anti-inflammatory properties are also suitable for formulas that treat acne and soothe sensitive skin, helping to improve skin health.

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Side Effects of Mangiferin

Although mangiferin is considered safe at conventional doses, its potential side effects warrant attention. Animal studies have shown that liver or kidney toxicity may be observed at very high doses, although these occur at doses far exceeding the effective dose. Human side effects have been reported to be relatively mild, primarily including gastrointestinal discomfort such as diarrhea or abdominal cramps.

It is worth noting that mangiferin may interact with certain medications (such as anticoagulants and hypoglycemic agents) and affect their metabolism, posing a risk of altering their efficacy. Therefore, water-soluble Mangiferin in Mango is recommended to consult a healthcare professional before using it as a dietary supplement for extended periods or at high doses, especially for pregnant women, breastfeeding women, and those taking long-term medications, to ensure safe use.

Where to buy Water Soluble Mangiferin15%？

Healthkintai^® is a Mangiferin manufacturer and supplier, specializing in providing 15%-98% Mangiferin Powder at competitive prices. Whether you're looking to purchase or wholesale in bulk, contact us today for a personalized quote. If you want to buy 15% water-soluble Mangiferin in Mango, please feel free to contact us at health@kintaibio.com.

FAQ

Q1:What class of chemical is mangiferin?

A1:Mangiferin is chemically classified as a carbon-glycoside derivative of xanthone. Specifically, its core structure is an xanthone core, a unique skeleton composed of a tricyclic system. In this structure, a glycosyl group (usually β-D-glucose) is directly linked to the core via a carbon-carbon bond (C-C bond), forming a stable C-glycosidic bond. This structural feature distinguishes it from O-glycosides linked by oxygen atoms and directly determines its significant chemical stability and various biological activities, such as antioxidant and anti-inflammatory effects. Therefore, mangiferin is a very important and widely studied class of phenolic compounds among natural products.

Q2:What sickness can mango leaf cure?

A2:Traditionally, preparations from mango leaves have been used in various folk medicines to aid in managing conditions like diabetes, hypertension, fever, and diarrhea. Modern research, particularly on its main bioactive compound mangiferin, has shown promising anti-inflammatory, antioxidant, and anti-diabetic properties in laboratory and animal studies. For instance, it may help lower blood sugar and protect blood vessels.Mango leaf should be considered a complementary approach for wellness support, not a replacement for professional medical diagnosis and treatment. Always consult a healthcare provider before using it for any health condition.

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