Sanguinarine Powder

Sanguinarine Powder is a natural botanical extract derived from plants of the Macleaya cordata genus, with CAS number 2447 - 54 - 3. It is a bioactive alkaloid compound that has garnered significant attention in various industries.

Healthkintai^® stands as a leading producer of Macleaya Cordata Extract 60% total alkaloids( (Sanguinarine>40%,chelerythrine>15%). Through advanced extraction and purification technologies, we deliver pharmaceutical-grade quality, with the key bioactive compound Sanguinarine maintained in its core form, ensuring high bioavailability for diverse applications. Please feel free to contact us at health@kintaibio.com.

In selecting raw materials for our 40%Sanguinarine products, we implement a stringent and traceable raw material management system. We exclusively cultivate and carefully Macleaya cordata from designated GACP (Good Agricultural and Collection Practice) compliant sites as the sole plant for Sanguinarine. This ensures correct species identification and genetic purity. The harvesting is meticulously scheduled to coincide with the plant's peak physiological stages—typically the fruiting period and the peak of vegetative growth—when the biosynthesis of benzylisoquinoline alkaloids, particularly Sanguinarine and Chelerythrine, is empirically proven to be at its maximum concentration.

The core of quality control lies in the quantitative analysis of the main alkaloid components. Our Macleaya cordata extract is produced using modern chromatographic technology, specifically high-performance liquid chromatography, to accurately determine the content of key components such as sanguisorbin and chelidonine, ensuring batch-to-batch stability and standardization.

                                                                                                                                    KINTAI Sanguinarine Powder COA 

Sanguinarine is a benzophenanthridine alkaloid with a complex mechanism of action and multi-target properties. Its core function lies in its ability to broadly interfere with key intracellular biological processes.

It interferes with the cell cycle and DNA function. Sanguinarine can embed itself in the DNA double helix, forming a Sanguinarine-DNA complex. This not only directly inhibits DNA replication and transcription but also induces DNA damage, leading to cell cycle arrest, especially in the G2/M phase, thereby inhibiting cell proliferation. Inducing programmed cell death is one of its most significant characteristics. Sanguisorbin can induce apoptosis through multiple pathways. In the mitochondrial pathway, it causes mitochondrial membrane potential collapse, releasing cytochrome C, which in turn activates the caspase cascade.

Sanguinarine exerts its powerful antibacterial, anti-inflammatory, and anti-proliferative effects through multiple molecular pathways, including direct action on DNA, induction of oxidative stress and apoptosis, and inhibition of key enzyme activity.​​​​​​​

1. Animal Feed Additives

This is currently the most important and mature application area for sanguinarine. As a natural plant extract, it is widely used as a green feed additive in livestock production.

With its powerful broad-spectrum antibacterial (especially effective against Gram-negative bacteria) and anti-inflammatory properties, sanguinarine can effectively prevent and treat intestinal diseases in livestock and poultry, improve intestinal health, and thus largely replace growth-promoting antibiotics. It can improve feed conversion rate, promote nutrient digestion and absorption, thereby improving the daily weight gain and overall production performance of animals such as pigs and chickens. By regulating the balance of intestinal flora and inhibiting inflammatory responses, sanguinarine helps enhance the non-specific immunity of animals and reduce the incidence of disease.

2. Oral Care Products

Sanguinarine is one of the earliest and most widely used applications, mainly utilizing its antibacterial and anti-inflammatory properties. It can effectively combat oral pathogens (such as streptococci) that cause dental plaque and gingivitis. By controlling plaque and reducing inflammation, it is added to products such as Sanguinarine toothpaste and Sanguinarine mouthwash for the prevention and treatment of gingivitis and periodontal disease.

3. Agriculture and Horticulture

In agriculture, sanguinarine is primarily developed as a plant-derived pesticide. As a fungicide, it exhibits significant inhibitory activity against various agricultural pathogenic fungi (such as wheat scab and cucumber gray mold) and bacteria, and is unlikely to induce resistance. As an insecticide, it demonstrates contact and stomach poison activities against some agricultural pests (such as aphids and mites), making it an environmentally friendly candidate ingredient for green pesticides.

Sanguisorbine requires strict dosage control during application; otherwise, it may cause a series of toxic side effects. Its core toxic mechanism lies in its ability to effectively inhibit Na+/K+-ATPase (sodium-potassium pump) on the cell membrane, thereby disrupting the normal ion gradient inside and outside the cell, leading to severe cellular dysfunction. Specifically, local contact can irritate the skin and mucous membranes; oral overdose can cause severe gastrointestinal reactions such as nausea, vomiting, abdominal pain, and diarrhea. If the toxin is absorbed into the systemic circulation, it can produce more severe systemic poisoning symptoms, including respiratory distress, arrhythmia, hypotension, and even life-threatening conditions due to respiratory paralysis. Therefore, although it has applications in animal feed and oral care, its potential toxicity must be given high priority and strictly controlled.​​​​​​​

Our products hold international quality system certifications such as GMP, ISO9001:2015, ISO22000:2018, HACCP, KOSHER, and HALAL. Every batch of products you receive meets international standards for heavy metals, microbial residues, and the content of key active ingredients (such as sanguisorbin), ensuring stable and reliable quality. Furthermore, we offer professional customization services. Whether it's adjusting the total alkaloid content ratio to suit your needs (e.g., a specific concentration of sanguisorbin to chelidonine), or adapting different dosage forms and carriers, we can provide you with a customized solution. 

 If you require  Sanguisorbine powder, please feel free to contact us at health@kintaibio.com.