Sophora Japonica Extract Quercetin

Sophora Japonica Extract Quercetin is a flavonol compound that is widely distributed in the plant kingdom and has multiple biological activities. It has strong biological activity in antibacterial, anti-inflammatory, anti-allergic, and prevention of diabetic complications.

As a plant extract production factory, Healthkintai^® can provide customers with a large amount of uniform standard, high purity, high quality 98%quercetin. Customers can get the most favorable price by directly contacting the factory, and can also obtain samples for testing. Please feel free to contact us at health@kintaibio.com.

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After treatment with lipopolysaccharides (LPS), IκBα in alveolar epithelial cells undergoes phosphorylation and degradation, and the dissociated NF-κB can move from the cytoplasm to the nucleus, aggravating the inflammatory response. Pretreatment with quercetin can prevent this process, confirming that quercetin can inhibit the nuclear translocation of NF-κB to reduce the expression of TNF-α, IL-1 and IL-6, thereby exerting an anti-inflammatory effect.

Tripathi et al. found that hypoxia can induce increased expression of IKKα/β and NF-κB, thereby upregulating the expression of proinflammatory cytokines (such as TNF-α, interferon-γ) and cell adhesion molecules (vascular cell adhesion molecule-1, intercellular adhesion molecule-1 and P-selectin). Treatment with quercetin can inhibit the expression of the above factors to reduce hypoxia-induced transvascular leakage, indicating that quercetin can inhibit NF-κB expression to alleviate hypoxia-induced ALI. 

(Reference: Research progress on the mechanism of quercetin in preventing and treating acute lung injury) 

1. Powerful antioxidant, combating cell damage and aging

Quercetin is one of the most powerful natural antioxidants. It effectively neutralizes harmful free radicals produced by pollution, radiation, stress, and other factors in the body, reducing cellular damage caused by  "oxidative stress." Oxidative stress is a major contributor to wrinkles, organ dysfunction, and numerous chronic diseases. Daily intake of quercetin acts like a protective barrier, delaying the aging process at its root, maintaining cellular health and vitality, and laying a solid foundation for overall health.

2. Natural anti-allergy and immune system stabilization

Quercetin is best known as a "natural antihistamine." It stabilizes mast cells, preventing them from excessively releasing histamine and other inflammatory mediators that trigger allergic reactions. For those suffering from hay fever, allergic rhinitis, or itchy skin, Sophora Japonica Extract Quercetin can significantly relieve symptoms such as sneezing, runny nose, and itchy eyes. By modulating the immune system, it offers a gentler, less drowsy alternative to traditional allergy medications.

3. Maintaining Cardiovascular Health

Quercetin has multiple protective effects on the cardiovascular system. It helps relax and soften blood vessels, improves endothelial function, and thus assists in regulating blood pressure. Its anti-inflammatory properties also help prevent the oxidation of "bad" cholesterol, reduce plaque deposition on blood vessel walls, and inhibit the development and progression of atherosclerosis. Long-term quercetin supplementation is considered an effective nutritional support strategy for preventing cardiovascular diseases such as hypertension and coronary heart disease.

4. Anti-Inflammation and Enhanced Performance

Quercetin effectively inhibits the activity of various pro-inflammatory factors, making it particularly effective in alleviating chronic inflammation. For athletes or fitness enthusiasts, post-workout quercetin supplementation can significantly reduce muscle inflammation and soreness, accelerating recovery. Furthermore, research suggests that it may improve mitochondrial function and enhance endurance. For arthritis patients, its anti-inflammatory effects can also help reduce joint swelling and pain, improving mobility.

Despite its high safety profile, caution is advised in the following situations:

• Gastrointestinal discomfort: This is the most common adverse reaction. Higher doses of quercetin may cause mild headaches, heartburn, nausea, or tingling.
• Interactions with Certain Drugs : Quercetin may affect the metabolism of certain drugs by inhibiting a group of enzymes in the liver called cytochrome P450 (specifically CYP3A4 and CYP2C9). This can lead to abnormally high blood levels of the drug, increasing the risk of side effects or toxicity.
• Pregnant and Breastfeeding Women: Due to a lack of sufficient safety data, Sophora Japonica Extract Quercetin supplements are generally not recommended for pregnant and breastfeeding women out of an abundance of caution. It is safe to take with food.

1. Pharmaceuticals and Healthcare Products

In the pharmaceutical and healthcare sector, this extract is an ideal raw material for developing natural anti-allergy products. Quercetin stabilizes mast cells, inhibiting histamine release at the source, effectively alleviating symptoms such as allergic rhinitis and asthma, earning it the nickname "natural antihistamine." Furthermore, its potent antioxidant and anti-inflammatory properties protect the vascular endothelium and reduce the risk of bad cholesterol oxidation, providing crucial nutritional support for preventing cardiovascular and cerebrovascular diseases such as hypertension and arteriosclerosis. It is widely used in dietary supplements such as capsules and tablets.

2. Functional Foods and Sports Nutrition

As a highly effective natural antioxidant, this extract is incorporated into functional foods such as sports drinks and energy bars. For athletes, it effectively scavenges the large amounts of free radicals produced by intense exercise, reducing oxidative damage and inflammatory responses in muscle cells, significantly alleviating post-exercise muscle soreness and accelerating recovery. This application directly addresses modern consumers' demand for "clean label" and natural, healthy ingredients.

3. Cosmetics and Pet Health

In the cosmetics industry, quercetin's antioxidant properties are used in anti-aging serums and creams to combat UV damage and slow the onset of wrinkles. Its anti-inflammatory properties are also used to soothe sensitive and damaged skin. In the pet health market, it is also formulated into specialized supplements to relieve itching, redness, and swelling caused by environmental allergies in dogs, and to support arthritic pets by reducing inflammation and pain, thereby improving their quality of life.

• High Purity: 98% high-purity Sophora Japonica Extract Quercetin and a highly concentrated concentration of active ingredients ensure significantly superior biological activity and stability compared to standard products, providing a reliable foundation for R&D and application.
• Customizability: Flexibly tailored to meet specific customer requirements for particle size, packaging, and other aspects, precisely matching the unique formulations of different production processes and end products.
• Wide Application: Its excellent antioxidant and anti-inflammatory properties enable its widespread application in pharmaceuticals, functional foods, health supplements, cosmetics, and other fields, driving product innovation and value enhancement.

Q1:Is Sophora japonica the same as quercetin?

A1:Extracted from the Sophora japonica flower, quercetin is a flavonoid (and more specifically flavonol), a pigment of the colour of flowers, fruits and vegetables.  

Q2: Are there any side effects?

A2: Quercetin is generally safe but may cause mild effects (e.g., stomach upset, headache) in rare cases. Avoid if pregnant, nursing, or taking certain medications (e.g., blood thinners).